Sugar-based Excipients have an expanding application base, with many products being used in the pharmaceutical industry. The rise in generics and the finish of many bestselling drugs is driving growth in this industry. These excipients are also used in new formulation technologies, including tablets and orally disintegrating products. While some of these excipients are granular, others are in the form of sugar alcohol.
The use of Sugar-based Excipients has become commonplace in pharmaceutical tableting. These compounds help mask the bitter taste of active ingredients and make the product more palatable. Direct compression is the preferred method for manufacturing tablets, and thus demand for compaction-friendly excipients has grown. Fructose and crystalline maltose are two new excipients with excellent compressibility and taste-masking properties. These excipients are generally used in the preparation of medicines, particularly oral medications. They are particularly important for medicines that have an active ingredient coordinated to its sugar. Among Sugar-based Excipients are dextrose, sucrose, sorbitol, and glycerol. These sugars are used for flavoring and as taste-concealing materials. They are also used in patient syrups. While these excipients have an easy dissolution rate and good compatibility and compressibility, these ingredients are not always a good match for the stringent government regulations. The European Medicines Agency requires a justification for sugar-based products when used in medications. However, there is hope for these excipients to become a more widely used ingredient in pharmaceuticals. The growth is attributed to the increasing use of co-processed sugar excipients and rapid growth of the generics following patent expiry. However, the market is limited by stringent regulatory requirements, and the lack of FDA-approved manufacturing facilities. Further, the high cost of these excipients may hinder the market growth. Another type of excipient is sucrose. Sucrose, glucose, and glycerol are examples of these Sugar-based Excipients. They are used primarily in the manufacture of antibiotics and patient syrups. In addition, sucrose is used in the production of coatings and flavoring agents to enhance pharmaceutical products and make them more appealing to the consumer. Alcohol-based sugar excipients are another popular choice. These products are white and granular, much like sugar. They are used as sugar alternatives, and their sweetness level can range from 50% to 100% of that of sugar. These excipients are versatile enough to adapt to emerging formulation technologies. The market can be classified into three broad categories: powders/granules and fillers/diluents. The powders and granules segment accounts for the largest share of this market, followed by the parenteral and topical products segments. Furthermore, these excipients are widely used in pharmaceuticals, which makes them ideal for a wide range of applications. However, the market is facing several hurdles, such as the lack of FDA-approved manufacturing sites and high cost of production. Therefore, the growth of these Sugar-based Excipients will be dependent on the adoption of novel technologies. The key factors driving the market growth are rising consumer awareness, increased pharmaceutical industry expansion, increasing prevalence of chronic disease, and the development of innovative products.
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